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Pharmacology: Action on Blood Coagulation: Small amounts of heparin in combination with antithrombin III (heparin cofactor) can inhibit thrombosis by inactivating activated factor X and inhibiting the conversion of prothrombin to thrombin. Once active thrombosis has developed, larger amounts of heparin can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin.
Heparin and Lipoprotein Lipase: In vivo heparin clears liperemic plasma by stimulating the release and activation of lipoprotein lipase which hydrolyzes triglycerides to free fatty acid and glycerol. This effect may occur following dose of heparin that are smaller than those required to produce anticoagulant effects. Bound hyperlipemia has been reported following a period of heparin-induced plasma clearing.
